منابع مشابه
High-affinity analogues of neuropeptide Y containing conformationally restricted non-proteinogenic amino acids.
High-afnnity analogues of neuropeptide Y containing conformationally restricted non-proteinogenic amino acids Annette G. Beck-Sickinger*t, Eike Hoffmann*, Klaus Padinit, Hans-Ulrich Reissigt, Klaus-Dieter WillimQ, Heike A. WielandQ and Gunther Jung* *Institute of Organic Chemistry, University of Tubingen, Auf der Morgenstelle 18, D-72076 Tubingen, Germany, $Institute of Organic Chemistry, Techn...
متن کاملSolubility of the Proteinogenic α-Amino Acids in Water, Ethanol, and Ethanol–Water Mixtures
The addition of organic solvents to α-amino acids in aqueous solution could be an effective method in crystallization. We reviewed the available data on the solubility of α-amino acids in water, water-ethanol mixtures, and ethanol at 298.15 K and 0.1 MPa. The solubility of l-alanine, l-proline, l-arginine, l-cysteine, and l-lysine in water and ethanol mixtures and the solubility of l-alanine, l...
متن کاملCurrent and prospective applications of non-proteinogenic amino acids in profiling of proteases substrate specificity.
Proteases recognize their endogenous substrates based largely on a sequence of proteinogenic amino acids that surrounds the cleavage site. Currently, several methods are available to determine protease substrate specificity based on approaches employing proteinogenic amino acids. The knowledge about the specificity of proteases can be significantly extended by application of structurally divers...
متن کاملFirst-principles data set of 45,892 isolated and cation-coordinated conformers of 20 proteinogenic amino acids
We present a structural data set of the 20 proteinogenic amino acids and their amino-methylated and acetylated (capped) dipeptides. Different protonation states of the backbone (uncharged and zwitterionic) were considered for the amino acids as well as varied side chain protonation states. Furthermore, we studied amino acids and dipeptides in complex with divalent cations (Ca(2+), Ba(2+), Sr(2+...
متن کاملNon-proteinogenic Amino Acids in Lacticin 481 Analogues Result in More Potent Inhibition of Peptidoglycan Transglycosylation
Lantibiotics are ribosomally synthesized and post-translationally modified peptide natural products that contain the thioether structures lanthionine and methyllanthionine and exert potent antimicrobial activity against Gram-positive bacteria. At present, detailed modes-of-action are only known for a small subset of family members. Lacticin 481, a tricyclic lantibiotic, contains a lipid II bind...
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ژورنال
عنوان ژورنال: Nature Methods
سال: 2020
ISSN: 1548-7091,1548-7105
DOI: 10.1038/s41592-020-0741-z